Serum cytokine levels in GH-deficient children during substitutive GH therapy
نویسندگان
چکیده
منابع مشابه
Three-Year Follow-up Study on Serum Leptin Levels in GH Deficient Children with GH Replacement Therapy
Interactions between GH and leptin have been extensively studied. However, results of long-term GH therapy on serum leptin levels in GH-deficient children were not consistent. Moreover, no such reports were available in Japanese children with this disease. We studied 35 Japanese patients with GH deficiency (26 boys and 9 girls, mean age: 9.8 ± 6.2 yr old), of whom 6 patients with complete and 2...
متن کاملSerum leptin levels during recombinant human GH therapy in adults with GH deficiency.
OBJECTIVE Recent studies suggest an involvement of the obese (OB) gene and its product leptin in the regulation of body fat. Since adults with growth hormone deficiency (GHD) have a high body fat mass which can be normalized with recombinant human (rh) GH therapy, we investigated whether GH influences serum leptin directly or indirectly via its lipolytic effect. DESIGN Fourteen adults with GH...
متن کاملThe effect of GH treatment on serum FGF23 and Klotho in GH-deficient children.
BACKGROUND Normal phosphate homeostasis is essential for normal linear growth. The phosphaturic fibroblast growth factor 23 (FGF23)/Klotho axis is a major regulator of phosphate homeostasis; therefore, an intact FGF23/Klotho axis is important for normal linear growth. On the other hand, GH/IGF1 axis has opposing effects on phosphate homeostasis, but the underline mechanisms remain unclear. AI...
متن کاملLong-term results of GH therapy in GH-deficient children treated before 1 year of age.
OBJECTIVES To evaluate the long-term effects of GH therapy in early diagnosed GH-deficient patients treated before 1 year of age. STUDY DESIGN We studied all 59 patients (33 males) recorded by Association France-Hypophyse and treated with GH (0.50+/-0.15 IU/kg (S.D.) per week) before 1 year of age. Clinical presentation and growth parameters under GH treatment were analyzed. RESULTS Neonata...
متن کاملRelevance of IGF-I, IGFBP-3, and IGFBP-2 measurements during GH treatment of GH-deficient and non-GH-deficient children and adolescents.
BACKGROUND Little information is available on the relevance of parameters representing the insulin-like growth factor (IGF) system with regard to growth hormone (GH) treatment during childhood. In adults, high IGF-I levels were found to be associated with side effects and long-term risks. AIM/METHOD Our aim was to monitor the serum levels of IGF-I, IGF-binding protein (IGFBP) 3, and IGFBP-2 d...
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ژورنال
عنوان ژورنال: European Journal of Endocrinology
سال: 2005
ISSN: 0804-4643,1479-683X
DOI: 10.1530/eje.1.01827